She was born early and tiny, at 5 pounds, 11 ounces, with chunky, pink cheeks and a dash of brown hair. Baby Isabella, 2 weeks old and swaddled in a hospital blanket, also was born addicted to opioids. The preemie — who arrived Nov. 2 in Colorado Springs, about five weeks early — was one of six babies recently in the neonatal intensive care unit at UCHealth Memorial Hospital going through opioid withdrawals because of their mothers’ drug use. The rise in Colorado newborns addicted to opioids has alarmed physicians and child advocates, jumping 83 percent from 2010 to 2015. The state’s rate, according to the Colorado health department, climbed from 2 births out of 1,000 to 3.6 births in that five-year period. In some parts of Colorado, the rate is much higher. At Parkview Medical Center in Pueblo, the city’s safety-net hospital that sees many Medicaid patients, the rate of newborns addicted to opioids skyrocketed from 0.7 per 1,000 in 2010 to 20.8 in 2012. The rate at Parkview now hovers around 10, and doctors have noted a shift from prescription drugs such as Oxycontin to street drugs, mainly heroin, in recent years. For Isabella, the symptoms of neonatal abstinence syndrome — when newborns go through opioid withdrawal — were mild. She came close to needing methadone, but doctors, nurses and her parents were able to get Isabella through the worst of it with cuddling and skin-to-skin contact. The infant has had an elevated temperature, loose stools and trouble latching on to drink milk. The reason Isabella didn’t suffer the most severe symptoms of the syndrome — tremors, seizures, inconsolable crying, sweating and inability to sleep — was that her mother had stopped using heroin and was in treatment during pregnancy, taking a daily opioid pill to stop the cravings. “There we go, sugar buns,” said Isabella’s mother, Rachel, while pulsing a finger into her baby’s cheek to try to get the infant to suck a bottle. Rachel, 30, didn’t want her last name used in this story because she is trying to put her life back together after years of addiction to Oxycontin, Percocet and heroin. Rachel and her husband lost their house. He was kicked out of the Army. Their son — 3